Hydroxyapatite (HAp, Ca10(PO4)6(OH)2) found in the human bone structure is a non-toxic bioceramic with high biocompatibility, bioactivity and osteoconduction. Hydroxyapatite enhances bone formation by using biomedical application such as treatment of bone fractures, cracks and patching with excellent biocompatibility and bioactivity. Among the methods used in the synthesis of hydroxyapatite, biomimetic method is the only method that can be produced in physiological body conditions (pH 7.2) and at low temperature (37°C). Collagen (Col) and HAp are the two main constituents of bone tissue. 3D porous Col-HAp composite scaffolds, which can be biodegraded over time and replaced by new bone tissue, as well as biocompatibility supported by cell assays to increase the mechanical properties of HAp addition, have an important place in the biomedical field.
